Description
JNJ-42165279 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH) with IC50 of 70nM for hFAAH; no inhibition on CYPs and hERG at 10uM; blocks FAAH in the brain and periphery of rats, causes an elevation of the concentrations of AEA, OEA, and PEA; demonstrates activity in the spinal nerve ligation (SNL) model of neuropathic pain; exhibited excellent ADME and pharmacodynamic properties. Anxiety Phase 2 Clinical